Natasha Lyonne's decision to not have children is a personal one, and it is important to respect her choice. She has stated that she is "not wired to be a mom" and that she is "very happy" with her life the way it is. This suggests that she has a strong sense of self and that she is comfortable with her own life choices.
It is important to remember that the decision of whether or not to have children is a deeply personal one. There is no right or wrong answer. Natasha Lyonne has made the decision that is best for her, and she should be respected for that.